Welcome to the repeatome

A new frontier in biology
A new way to conquer disease

Vast stretches of human DNA have long been dismissed as junk. Most of this “dark genome” is comprised of repetitive sequences, collectively known as the repeatome. We have now discovered that these repeats can play a critical role in human health, such as by switching on the innate immune response under stress.

Unlocking the repeatome will enable us to discover powerful new classes of medicines for cancer and autoimmune diseases.

That is our mission at ROME.

Latest news and presentations

June 30, 2022

ROME Therapeutics Announces Publication of First Crystal Structure of a Human Endogenous Reverse Transcriptase in PNAS

June 30, 2022

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition  |  PNAS

June 5-9, 2022

Sensitive Detection of LINE-1 Retrotransposition Across Cancer Uncovers Biological Correlates | The Mobile DNA Conference: Evolution, Diversity, and Impact