Director, Medicinal Chemistry


Company:           ROME Therapeutics

Location:             Cambridge, MA

Reports to:          SVP, Chemistry

Who We Are

ROME Therapeutics is developing novel therapies for cancer and autoimmune diseases by harnessing the power of the repeatome – vast stretches of uncharted genetic material that have long been dismissed as the “dark genome.” With several drug targets identified and multiple discovery programs underway, ROME is moving rapidly to leverage this new frontier in biology. To lead this exploration, ROME has assembled a team of world-class leaders across fields including oncology, immunology, virology, chemistry and machine learning. ROME is based in Cambridge, Mass. For more information, please visit

What You’ll Do

  • Contribute to multi-disciplinary drug discovery and development teams by developing and implementing medicinal chemistry strategies to discover novel therapeutics
  • Prioritize medicinal chemistry activities and manage external chemistry resources to achieve project goals
  • Design high-quality small molecules considering physicochemical properties and pharmacological readouts
  • Possess a clear and effective communication style to disseminate project data and medicinal chemistry approach to both internal colleagues and external collaborators
  • Build and maintain productive relationships with internal and external colleagues in chemistry, structural biology, ADME, biology and pharmacology
  • Contribute to the building the chemistry infrastructure of ROME (e.g. cheminformatics and compound collection strategy)
  • Lead the preparation of patent documents, peer reviewed scientific publications and regulatory documents, as appropriate

What You’ll Bring

  • Ph.D. in Organic Chemistry or Medicinal Chemistry with 10+ years of experience working in a pharmaceutical and/or biotechnology setting as a medicinal chemist
  • Demonstrated leadership in drug discovery solving a variety of medicinal chemistry problems (e.g. solubility, metabolism, and off-target activities) as evidenced by a strong record of scientific accomplishment and success delivering pre-clinical and clinical candidates
  • Experience in hit identification through preclinical development
  • Proven ability to manage timelines and resources to drive projects toward key decision criteria
  • Strong synthetic chemist and experience using structure-based drug design to design clinical candidates
  • Comfortable working in a hybrid environment as needed.
  • Vaccination against COVID-19 is mandatory, subject to medical and religious accommodations, and proof of vaccination must be provided to ROME

Who You’ll Work With

All Roman citizens exemplify our core values.  Romans are encouraged to BE BOLD, DELIVER EXCELLENCE and to CARE DEEPLY in our pursuit of discovering and delivering medicines to patients in need. Relentless curiosity means that we continually strive to improve, learn, and grow by asking questions, seeking knowledge, and stretching beyond our comfort zone. We rely on each other to know our stuff, follow through and to ‘GSD – get stuff done’. We are inspired to operate with respect and kindness, valuing differences and authenticity.


Rome prides itself on competitive compensation.

How to Apply

Please send a cover letter and a copy of your CV to

Rome Therapeutics is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.