Scientist/Principal Scientist, In Vitro Pharmacology

 

POSITION DESCRIPTION

Position               Scientist/Principal Scientist, In Vitro Pharmacology

Company            ROME Therapeutics

Location             Cambridge, MA

Reports to          VP, Oncology

Who We Are

ROME Therapeutics is developing novel therapies for cancer and autoimmune diseases by harnessing the power of the repeatome – vast stretches of uncharted genetic material that have long been dismissed as the “dark genome.” With several drug targets identified and multiple discovery programs underway, ROME is moving rapidly to leverage this new frontier in biology. To lead this exploration, ROME has assembled a team of world-class leaders across fields including oncology, immunology, virology, chemistry and machine learning. ROME is based in Cambridge, Mass. For more information, please visit www.rometx.com.

Rome Therapeutics is seeking an enthusiastic and experienced in vitro pharmacologist to develop and execute robust disease-relevant biochemical and cellular assays to support lead discovery and optimization.  You will implement a broad range of techniques to understand pharmacology of agents directed against therapeutic targets in the repeatome.  You will have experience in optimizing and validating assays for low and high-throughput screening using biochemical, protein-protein interaction, gene/protein expression, and high content assay readouts. You will work closely with cross-functional teams to drive structure activity relationships and be a major contributor to the advancement and characterization of drug candidates.

What You’ll Do

  • Independently design, develop, and validate broad biochemical and cell-based assays to support drug discovery and development projects
  • Work closely with the chemistry team to understand structure activity relationship to enable lead identification, optimization, and characterization
  • Work in partnership with colleagues in the biology group to ensure that assays and experiments are designed optimally, biologically relevant, aligned with goals, and implemented effectively
  • As the in vitro pharmacology representative, communicate strategies, plans, results, timelines, and challenges to core teams, project teams and leadership
  • Potentially build and lead a team of Research Associates/Scientists
  • Provide mentorship and guidance to junior Scientists while excelling as an independent, valuable contributor
  • Maintain an awareness of current developments in the literature around your targets and relevant technologies to enhance functional capability and productivity

What You’ll Bring

 Experience and Qualifications

  • BS, MS or Ph.D. in biochemistry, molecular biology, cell biology, or a related field with > 5 years’ industry experience in biological assays/in vitro pharmacology
  • Proficiency in developing and implementing potency, selectivity, and mechanistic assays to drive drug discovery and optimization
  • Hands-on experience in the development and optimization of a wide range of cellular assays such as indicator gene/protein (luciferase, HiBit), HTRF, AlphaLISA, MSD, qPCR
  • Experience in diverse molecular and cell biology techniques, including siRNA, CRISPR, and immunoassays
  • Proficiency in utilizing software such as Live Design, Spotfire and GraphPad for data analysis and figure generation
  • Strong attention to detail and the ability to balance multiple objectives at the same time
  • Ability to collaborate in a multidisciplinary and dynamic environment
  • Effective communication skills (oral and written)
  • Pro-active and resourceful problem solver
  • Flexibility necessary for success in a dynamic early-stage Biotech company
  • Strong cross-functional collaboration skills with a focus on trust, credibility, and respect
  • Willingness to ask questions, be open to new ideas, and embrace ambiguity
  • Ability and willingness to be candid and genuine
  • Proven track record of functional expertise and following through on commitments
  • Comfortable working in a virtual environment with distributed team members
  • Vaccination against COVID-19 is mandatory, subject to medical and religious accommodations, and proof of vaccination must be provided to ROME
  • Willingness to working in a hybrid (in-person/remote) work environment as needed
  • Vaccination against COVID-19 is mandatory, subject to medical and religious accommodations, and proof of vaccination must be provided to ROME

 Who You’ll Work With

All Roman citizens exemplify our core values. Romans are encouraged to BE BOLD, DELIVER EXCELLENCE and to CARE DEEPLY in our pursuit of discovering and delivering medicines to patients in need. Relentless curiosity means that we continually strive to improve, learn, and grow by asking questions, seeking knowledge, and stretching beyond our comfort zone. We rely on each other to know our stuff, follow through and to ‘GSD – get stuff done’. We are inspired to operate with respect and kindness, valuing differences and authenticity.

COMPENSATION AND BENEFITS

ROME offers competitive compensation and benefits.

 HOW TO APPLY

Please send a cover letter and a copy of your CV to careers@rometx.com

ROME Therapeutics is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.