Director of Data Science (Algorithms for Raw Genomic Data)


Position           Director of Data Science (Algorithms for Raw Genomic Data)

Company         ROME Therapeutics

Location          Cambridge, MA; or, Remote

Reports to       Head of Data Science

Who We Are

ROME Therapeutics is developing novel therapies for cancer and autoimmune diseases by harnessing the power of the repeatome – vast stretches of uncharted genetic material that have long been dismissed as “junk DNA.” With several drug targets identified and multiple discovery programs underway, ROME is moving rapidly to leverage this new frontier in biology. To lead this exploration, ROME has assembled a team of world-class leaders across fields including oncology, immunology, virology and machine learning. ROME was launched in April 2020 and was incubated at GV, in collaboration with ARCH Venture Partners and Partners Innovation Fund. ROME is based in Cambridge, Mass. For more information, please visit

ROME Therapeutics is seeking an experienced Data Scientist and technical leader with an extensive background in computational biology and genomics to develop novel genomics and applied machine learning algorithms, put them into a production software system, and apply them to large-scale and custom datasets. The successful candidate will likely be a generalist Data Scientist with technical leadership experience, alongside very strong technical skills in computational molecular biology (algorithms for raw next-generation sequencing data), statistics and machine learning, data visualization, software engineering and deployment of data processing pipelines, and excellent communication skills.

What You’ll Do

  • Provide technical leadership to a team of Data Scientists in developing prototype genomics and machine learning algorithms, along with guidance in scaling those up
  • Define and implement prototype analytical solutions to solve complex genomics problems (processing raw next-generation sequencing data), relying on statistics, machine learning, and other computational tools
  • Implement prototype computational biology and bioinformatic pipelines that process and analyze genomics, transcriptomics, and proteomics datasets
  • Build and evaluate novel predictive models of disease
  • Establish new methods for analyses of structured and unstructured datasets to drive decision-making for repeatome-based therapeutic programs
  • Resourcefully mine publicly available data to gain insights
  • Work with bench scientists to apply approaches that improve experimental design and interpretation of results
  • Build prototype dashboards that capture and visualize Data Science output
  • As part of Rome’s cross-functional team, collaborate effectively by communicating analytic results to internal and external scientists, as well as business executives
  • Contribute to Rome’s culture of scientific rigor and innovative excellence

 What You’ll Bring

Experience and Qualifications

  • Technical leadership experience required (managerial experience is a plus)
  • 8+ year(s) experience in industry (some of which can be in post-graduate academia)
  • PhD in Computer Science (or equivalent Engineering degree), with strong training and experience in Computational Biology, Statistics, and Machine Learning
  • Strong background in developing complex algorithms for high-throughput analyses of raw next-generation sequencing data
  • Expertise in analysis of large-scale genomics datasets (DNA sequencing, RNA sequencing, proteomics) and appropriate statistical methods
  • Familiarity with oncology and/or autoimmune diseases is a plus
  • Demonstrated track record, including scientific publications, of analyzing large biological datasets
  • Very strong programming skills (Python preferred)
  • Effective communication skills (oral and written)
  • Pro-active and resourceful problem solver
  • Flexibility necessary for success in a dynamic early-stage Biotech company
  • Ability to manage multiple complex projects simultaneously
  • Strong cross-functional collaboration skills with a focus on trust, credibility, and respect
  • Willingness to ask questions, be open to new ideas, and embrace ambiguity
  • Ability and willingness to be candid and genuine
  • Proven track record of functional expertise and following through on commitments
  • Comfortable working in a virtual environment with distributed team members 

Who You’ll Work With

All Roman citizens exemplify our core values.  Romans are encouraged to BE BOLD, DELIVER EXCELLENCE and to CARE DEEPLY in our pursuit of discovering and delivering medicines to patients in need. Relentless curiosity means that we continually strive to improve, learn, and grow by asking questions, seeking knowledge, and stretching beyond our comfort zone. We rely on each other to know our stuff, follow through and to ‘GSD – get stuff done’. We are inspired to operate with respect and kindness, valuing differences and authenticity.


ROME offers competitive compensation and benefits.


Please send a cover letter and a copy of your CV to

ROME Therapeutics is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.